Bono and The Edge perform with a variety of guests during A Night of Music: Celebrating 10 Years of ONE and (RED). They're supported by the New York-based Orchestra of St. Luke's on each song except "When Love Comes To Town." The Congo-based Orchestre Symphonique Kimbanguiste also provides backing on "Angel Of Harlem," "I Still Haven't Found What I'm Looking For" and "One." Edge plays piano on both "Every Breaking Wave" and "Stuck In A Moment." Jessie J sings the second verse of "One" and even lets the crowd sing a couple lines for her, much like Bono does in concert. Miley Cyrus struggles with the third verse, asking for help before she even gets started, so Bono takes over and keeps the song going.

Bono also delivers a short speech about the success of (RED) and ONE at the beginning of the event. The concert is private and no tickets are sold to the public.